2. Signaling Pathways
  3. Immunology/Inflammation
    Vitamin D Related/Nuclear Receptor
  4. Glucocorticoid Receptor

Glucocorticoid Receptor

Glucocorticoid Receptor

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Glucocorticoid Receptor (GR, or GCR) also known as NR3C1 (nuclear receptor subfamily 3, group C, member 1) is the receptor to which cortisol and other glucocorticoids bind. The GR is expressed in almost every cell in the body and regulates genes controlling the development, metabolism, and immune response. When the glucocorticoid receptor binds to glucocorticoids, its primary mechanism of action is the regulation of gene transcription. The unbound receptor resides in the cytosol of the cell. After the receptor is bound to glucocorticoid, the receptor-glucorticoid complex can take either of two paths. The activated GR complex up-regulates the expression of anti-inflammatory proteins in the nucleus or represses the expression of pro-inflammatory proteins in the cytosol by preventing the translocation of other transcription factors from the cytosol into the nucleus. Dexamethasone is an agonist, and RU486 and cyproterone acetate are antagonists of the GR. Also, progesterone and DHEA have antagonist effects on the GR.

Cat. No. Product Name Effect Purity Chemical Structure
  • HY-B0214S1
    Prednisone-d7
    		Agonist
    Prednisone-d7 (Dehydrocortisone-d7) is deuterium labeled Prednisone. Prednisone (Adasone) is a corticosteroid agent with anti-inflammatory and immunosuppressive effects that can be used to study diseases related to systemic lupus erythematosus.
    Prednisone-d<sub>7</sub>
  • HY-B1121R
    Flunisolide (Standard)
    		Activator
    Flunisolide (Standard) is the analytical standard of Flunisolide. This product is intended for research and analytical applications. Flunisolide is a corticosteroid, which is an orally active glucocorticoid receptor activator with anti-inflammatory activity. Flunisolide can induce eosinophil apoptosis, and is used for the research of asthma or rhinitis, and inflammation.
    Flunisolide (Standard)
  • HY-B1365R
    Prednicarbate (Standard)
    		Agonist
    Prednicarbate (Standard) is the analytical standard of Prednicarbate. This product is intended for research and analytical applications. Prednicarbate is a topical corticosteroid agent. Prednicarbate can be used for the research of inflammatory skin diseases, such as atopic dermatitis.
    Prednicarbate (Standard)
  • HY-13570BR
    Betamethasone acetate (Standard)
    Betamethasone acetate (Standard) is the analytical standard of Betamethasone acetate (HY-13570B). This product is intended for research and analytical applications. Betamethasone acetate is a glucocorticoid with prenatal application for preventing respiratory distress syndrome (RDS) in premature infants. Betamethasone acetate exhibits dose-dependent effects on somatic and brain development in offspring when administered prenatally to pregnant rats. Betamethasone acetate can be used for the study of antenatal intervention.
    Betamethasone acetate (Standard)
  • HY-W740175
    6b-Hydroxy triamcinolone acetonide
    		Control
    6b-Hydroxy triamcinolone acetonide is a metabolite of the synthetic corticosteroid Triamcinolone acetonide (HY-B0636). 6b-Hydroxy triamcinolone acetonide is formed from triamcinolone acetonide by the cytochrome P450 (CYP) isoforms CYP3A4, CYP3A5, and CYP3A7.
    6b-Hydroxy triamcinolone acetonide
  • HY-108243R
    AZD5423 (Standard)
    		Modulator
    AZD5423 (Standard) is the analytical standard of AZD5423 (HY-108243). This product is intended for research and analytical applications. AZD5423 is an inhaled, potent, selective, and non-steroidal glucocorticoid receptor (GR) modulator (SGRM). AZD5423 effectively reduces allergen-induced responses in subjects with mild allergic asthma.
    AZD5423 (Standard)
  • HY-13681S
    Methylprednisolone acetate-d6
    Methylprednisolone acetate-d6 is the deuterium labeled Methylprednisolone acetate (HY-13681). Methylprednisolone acetate, a prednisolone derivative, is a corticosteroid hormone. Methylprednisolone acetate can relieve pain and swelling that occurs with arthritis and other joint disorders in vivo.
    Methylprednisolone acetate-d<sub>6</sub>
  • HY-137919
    Fluticasone 17β-carboxylic acid
    		Control
    Fluticasone 17β-carboxylic acid is an intermediate in the synthesis of the glucocorticosteroid Fluticasone propionate (HY-B0154).
    Fluticasone 17β-carboxylic acid
  • HY-122213
    RU-25055
    		Antagonist
    RU-25055 is a potent antiglucocorticoid. RU-25055 inhibits early antigen production of the EpsteinBarr virus (EBV) by dexamethasone.
    RU-25055
  • HY-B1087R
    Prednisolone hemisuccinate (Standard)
    Prednisolone (hemisuccinate) (Standard) is the analytical standard of Prednisolone (hemisuccinate). This product is intended for research and analytical applications.
    Prednisolone hemisuccinate (Standard)
  • HY-N8550
    Cortolone
    		Control
    Cortolone (α-Cortolone) is a metabolite of the glucocorticoid cortisol (Hydrocortisone (HY-N0583)). Hydrocortisone is a steroid hormone or glucocorticoid secreted by the adrenal cortex.
    Cortolone
  • HY-B1834R
    Megestrol (Standard)
    		Agonist
    Megestrol (Standard) is the analytical standard of Megestrol. This product is intended for research and analytical applications. Megestrol is an orally active glucocorticoid and progesterone receptor agonist. Megestrol can alleviate anorexia, cachexia or unexplained significant weight loss associated with acquired immunodeficiency syndrome (AIDS). Megestrol may cause manifestations similar to those of glucocorticoids and increase the risk of mental disorders.
    Megestrol (Standard)
  • HY-B1616R
    Clobetasone butyrate (Standard)
    		Agonist
    Clobetasone butyrate (Standard) is the analytical standard of Clobetasone butyrate. This product is intended for research and analytical applications. Clobetasone butyrate is a synthetic glucocorticoid and has topical anti-inflammatory activity especially in skin. Clobetasone butyrate can be used to relieve corticosteroid-responsive dermatoses, including atopic dermatitis and psoriasis.
    Clobetasone butyrate (Standard)
  • HY-106673R
    Hydrocortisone buteprate (Standard)
    Hydrocortisone buteprate (Standard) is the analytical standard of Hydrocortisone buteprate. This product is intended for research and analytical applications. Hydrocortisone buteprate (Hydrocortisone probutate) is a medium potent, non-halogenated double-ester of hydrocortisone with a favorable benefit/risk ratio for the treatment of inflammatory skin disorders. Hydrocortisone buteprate (Hydrocortisone probutate) is available as a 0.1% cream or ointment formulation.
    Hydrocortisone buteprate (Standard)
  • HY-136642R
    Fluocinolone (Standard)
    		Agonist
    Fluocinolone (Standard) is the analytical standard of Fluocinolone (HY-136642). This product is intended for research and analytical applications. Fluocinolone is a potent steroid with highly selective glucocorticoid receptor agonist activity. Fluocinolone stabilizes the blood-retinal barrier by enhancing endothelial tight junctions, inhibiting the VEGF pathway and inflammatory factors. Fluocinolone has high lipophilicity, enabling long-term sustained release in the vitreous. Fluocinolone is used in research related to dermatological diseases, diabetic macular edema, uveitis and oral lichen planus.
    Fluocinolone (Standard)
  • HY-114835
    Roxibolone
    Roxibolone (BR-906) is a 2-carboxy-1, 4-androstadien-3-one derivative. Roxibolone exerts potent anti-glucocorticoid activity and can counteract its catabolism. Roxibolone has no androgenic activity. Roxibolone can be used for research of glucocorticoid-related metabolic disorders.
    Roxibolone
  • HY-B0154R
    Fluticasone propionate (Standard)
    		Agonist
    Fluticasone propionate (Standard) is the analytical standard of Fluticasone propionate. This product is intended for research and analytical applications. Fluticasone propionate, a potent topical anti-inflammatory corticosteroid, is a selective glucocorticoid receptor agonist, with an absolute affinity (KD) of 0.5 nM. Fluticasone propionate shows little or no activity at other steroid receptors. Anti-viral activity.
    Fluticasone propionate (Standard)
  • HY-17358R
    Loteprednol Etabonate (Standard)
    		Agonist
    Loteprednol Etabonate (Standard) is the analytical standard of Loteprednol Etabonate. This product is intended for research and analytical applications. Loteprednol etabonate (LE) is an orally active "soft" steroid belonging to a unique class of glucocorticoids. Loteprednol etabonate (LE) exhibits anti-inflammatory activity and has been used in optometry and ophthalmology.
    Loteprednol Etabonate (Standard)
  • HY-120016
    RU 43044
    		Antagonist
    RU 43044 is an orally active, selective glucocorticoid receptor inhibitor. RU 43044 blocks glucocorticoid receptor activity and reverses the enhanced dopamine release induced by high potassium in the prefrontal cortex. RU 43044 also inhibits thymocyte receptor down-regulation induced by high-dose glucocorticoids without affecting thymocyte apoptosis or basal receptor expression. RU 43044 is widely applicable to research related to depression.
    RU 43044
  • HY-B0415R
    Fluocinolone (Acetonide) (Standard)
    		Agonist
    Fluocinolone (Acetonide) (Standard) is the analytical standard of Fluocinolone (Acetonide). This product is intended for research and analytical applications. Fluocinolone is a glucocorticoid glucocorticoid receptor agonist. Fluocinolone is effective in preventing both lipid accumulation and inflammation. Fluocinolone can promote the proliferation of DPCs and has the potential role in repairing injured pulp tissues. Fluocinolone can be used to study the prevention of chemotherapy-induced peripheral neuropathy caused by Paclitaxel (HY-B0015).
    Fluocinolone (Acetonide) (Standard)
Cat. No. Product Name / Synonyms Application Reactivity